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  1. ESMO
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  4. ESMO-MCBS for Solid Tumours

ESMO-MCBS Scorecards

ESMO MCBS 1000x150

The ESMO-MCBS Scorecards provides a centralised location of cancer medicines approved by the European Medicines Agency and the US Food and Drug Administration that have been scored and published by ESMO.

ESMO-MCBS scores are based on peer reviewed clinical trial reports. They are generated using a validated standard methodology and are reviewed by a team of clinicians and statisticians before publication. ESMO-MCBS scores should be interpreted in the context of an evolving treatment landscape, in connection with clinical practice guidelines.

ESMO-MCBS Scores
Number of studies
Non-curative setting
5 22
4 135
3 156
2 55
1 24
NEB 4
Curative setting
A 54
C 3
NEB 3
ESMO-MCBS Scores by tumour type
Non-curative setting
Brain Tumours 4
Breast Cancer 39
Endocrine Tumours 21
Gastrointestinal Cancers 76
Genitourinary Cancers 70
Gynaecological Malignancies 38
Head and neck cancer 12
Non-cancerous soft-tissue tumour 1
Sarcoma 13
Skin Cancers 29
Thoracic Malignancies 86
TMB-H solid tumours 1
Tumour agnostic 6
Curative setting
Brain Tumours 2
Breast Cancer 9
Endocrine Tumours 0
Gastrointestinal Cancers 16
Genitourinary Cancers 3
Gynaecological Malignancies 1
Head and neck cancer 1
Non-cancerous soft-tissue tumour 0
Sarcoma 3
Skin Cancers 14
Thoracic Malignancies 11
TMB-H solid tumours 0
Tumour agnostic 0

The ESMO-MCBS Scorecards

reset selection
Evaluation form 1  For new approaches to adjuvant therapy or new potentially curative therapies
Evaluation form 2a For therapies that are not likely to be curative with primary endpoint of OS with separate sheets for:
Evaluation form 2b For therapies that are not likely to be curative with primary endpoint PFS with separate sheets for:
Evaluation form 2c  For therapies that are not likely to be curative with primary endpoint other than OS or PFS or equivalent (non-inferiority) studies
Evaluation form 3  For single-arm studies in orphan diseases and for diseases with high unmet need when primary outcome is PFS or ORR.
To evaluate ESMO-MCBS score adjustments based on quality of life .

My watchlist

    Tested Agent(s) Combined Agent(s) Control Arm Therapeutic Indication Tumour Type Tumour Sub-type Tumour Sub-group Trial Name Ref. Score Scorecard Scorecard
    Olaparib - Standard chemotherapy Treatment of patients with germline BRCA1/2 mutations, who have HER2-negative locally advanced or MBC who have been previously treated with an anthracycline and a taxane in the (neo)adjuvant or metastatic setting unless unsuitable for these treatments OlympiAD
    Breast Cancer
    		 Breast Cancer HER2- g-BrCa+ve OlympiAD

    4

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F2b
      4
    Tucatinib Trastuzumab + capecitabine Placebo, trastuzumab + capecitabine HER2-positive locally advanced or metastatic breast cancer after at least 2 prior anti-HER2 treatment regimes HER2CLIMB
    Breast Cancer
    		 Breast Cancer HER2+ HER2CLIMB

    4

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      4
    Binimetinib Encorafenib Vemurafenib In combination with encorafenib for the treatment of adult patients with unresectable or metastatic melanoma with a BRAF V600 mutation COLUMBUS
    Skin Cancers
    		 Cutaneous Melanoma BRAF V600 COLUMBUS

    A

    5

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a/F1
      5

      A
    Ramucirumab Erlotinib Placebo + Erlotinib First-line treatment of NSCLC with EGFR mutation RELAY
    Thoracic Malignancies
    		 Non-small-cell Lung Cancer EGFR+ RELAY

    3

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F2b
      3
    Durvalumab - Placebo Treatment of adult patients with unresectable, stage III NSCLC whose disease has not progressed following concurrent platinum-based CRT PACIFIC
    Thoracic Malignancies
    		 Non-small-cell Lung Cancer PD-L1 PACIFIC

    4

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      4
    Atezolizumab Nab-paclitaxel Placebo + nab-paclitaxel Treatment of patients with unresectable locally advanced or metastatic TNBC whose tumours have PD-L1 expression ≥1% and who have not received prior ChT for metastatic disease IMpassion130
    Breast Cancer
    		 Breast Cancer Triple-negative PD-L1+≥1% IMpassion130

    3

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F2b
      3
    Dab/Tram (dabrafenib and trametinib) - Placebo In combination with trametinib is indicated for the adjuvant treatment of adult patients with Stage III melanoma with a BRAF V600 mutation, following complete resection COMBI-AD
    Skin Cancers
    		 Cutaneous Melanoma BRAF V600 COMBI-AD

    NEB

    PRELIMINARY SCORE

    • DFS

    ADJUSTMENTS

    SCORE

    • F1
      NEB
    Pembrolizumab - Placebo EMA: Pembrolizumab for adjuvant treatment of adults and adolescents aged 12 years and older with stage IIB, IIC or III melanoma and who have undergone complete resection.. FDA: Pembrolizumab for the adjuvant treatment of patients with melanoma with involvement of lymph node(s) following complete resection. KEYNOTE-054
    Skin Cancers
    		 Cutaneous Melanoma - KEYNOTE-054

    A

    PRELIMINARY SCORE

    • DFS

    ADJUSTMENTS

    SCORE

    • F1

      A
    Nivolumab - Ipilimumab 10mg/kg Adjuvant treatment of adults and adolescents 12 years of age and older with Stage IIB or IIC melanoma, or melanoma with involvement of lymph nodes or metastatic disease who have undergone complete resection CheckMate 238
    Skin Cancers
    		 Cutaneous Melanoma - CheckMate 238

    NEB

    PRELIMINARY SCORE

    • RFS

    ADJUSTMENTS

    SCORE

    • F1
      NEB
    Abiraterone Prednisone + ADT (androgen deprivation therapy) ADT + placebo Indicated with prednisone or prednisolone for the treatment of newly diagnosed high risk metastatic hormone sensitive prostate cancer (mHSPC) in adult men LATITUDE
    Genitourinary Cancers
    		 Prostate cancer - LATITUDE

    4

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      4
    Apalutamide ADT (androgen deprivation therapy) ADT + placebo Treatment of non metastatic castration resistant prostate cancer (nmCRPC) in adult men who are at high risk of developing metastatic disease SPARTAN
    Genitourinary Cancers
    		 Prostate cancer - SPARTAN

    4

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      4
    Abiraterone Prednisone + ADT (androgen deprivation therapy) ADT + placebo Newly diagnosed high risk mHSPC in patients adult men STAMPEDE
    Genitourinary Cancers
    		 Prostate cancer - STAMPEDE

    4

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      4
    Enzalutamide ADT (androgen deprivation therapy) ADT Treatment of adult men with metastatic hormone-sensitive prostate cancer (mHSPC) in combination with androgen deprivation therapy ENZAMET
    Genitourinary Cancers
    		 Prostate cancer - ENZAMET

    4

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F2b
      4
    Enzalutamide ADT (androgen deprivation therapy) ADT + placebo Treatment of adult men with high-risk non-metastatic castration-resistant prostate cancer (CRPC) PROSPER
    Genitourinary Cancers
    		 Prostate cancer - PROSPER

    4

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      4
    Docetaxel ADT (androgen deprivation therapy) ADT In combination with androgen-deprivation therapy (ADT) for the treatment of patients with metastatic hormone-sensitive prostate cancer CHAARTED
    Genitourinary Cancers
    		 Prostate cancer - CHAARTED

    4

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      4
    Docetaxel ADT (androgen deprivation therapy) ADT In combination with androgen-deprivation therapy (ADT) for the treatment of patients with metastatic hormone-sensitive prostate cancer. CHAARTED
    Genitourinary Cancers
    		 Prostate cancer - CHAARTED

    4

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      4
    Docetaxel ADT (androgen deprivation therapy) ADT With or without prednisone or prednisolone, for the treatment of patients with metastatic hormone-sensitive prostate cancer STAMPEDE
    Genitourinary Cancers
    		 Prostate cancer - STAMPEDE

    4

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      4
    Darolutamide ADT (androgen deprivation therapy) ADT + placebo Non-metastatic castration resistant prostate cancer for adult men who are at high risk of developing metastatic disease ARAMIS
    Genitourinary Cancers
    		 Prostate cancer - ARAMIS

    3

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F2b
      3
    Apalutamide ADT (androgen deprivation therapy) ADT + placebo In adult men for the treatment of metastatic hormone-sensitive prostate cancer (mHSPC). TITAN
    Genitourinary Cancers
    		 Prostate cancer - TITAN

    4

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      4
    Pasireotide - Single arm Advanced carcinoids of the lung and thymus LUNA
    Endocrine Tumours
    		 Neuroendocrine Tumour - Lung and thymic carcinoids - LUNA

    3

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F3
      3
    Everolimus - Single arm Unresectable or metastatic, well-differentiated (Grade 1 or Grade 2) non-functional neuroendocrine tumours of gastrointestinal or lung origin in adults with progressive disease LUNA
    Endocrine Tumours
    		 Neuroendocrine Tumour - Lung and thymic carcinoids - LUNA

    3

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F3
      3
    Everolimus Pasireotide Single arm Advanced carcinoids of the lung and thymus LUNA
    Endocrine Tumours
    		 Neuroendocrine Tumour - Lung and thymic carcinoids - LUNA

    2

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F3
      2
    Cetuximab Cisplatin or carboplatin plus 5-FU Cisplatin or carboplatin plus 5-FU Treatment of patients with squamous cell cancer of the head and neck in combination with platinum-based chemotherapy for recurrent and/or metastatic disease EXTREME
    Head and neck cancer
    		 Squamous cell - EXTREME

    3

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      3
    Nivolumab - Investigator choice (methotrexate or cetuximab or docetaxel) As monotherapy is indicated for the treatment of recurrent or metastatic squamous cell cancer of the head and neck in adults progressing on or after platinum based therapy CheckMate141
    Head and neck cancer
    		 Squamous cell - CheckMate141

    5

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      5
    Rucaparib - Single arm Patients with platinum-sensitive, relapsed or progressive, BRCA-mut (germline and/or somatic), high-grade epithelial ovarian, fallopian tube or primary peritoneal cancer, who have been treated with ≥2 prior lines of platinum-based ChT, and who are unable to tolerate further platinum-based ChT. ARIEL2/Study 10
    Gynaecological Malignancies
    		 Ovarian, fallopian tubes and peritoneum cancer BRCA-mut ARIEL2/Study 10

    3

    PRELIMINARY SCORE

    • ORR

    ADJUSTMENTS

    SCORE

    • F3
      3
    Rucaparib - Placebo Maintenance treatment of patients with platinum sensitive relapsed high-grade epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in response (complete or partial) to platinum-based chemotherapy ARIEL3
    Gynaecological Malignancies
    		 Ovarian, fallopian tubes and peritoneum cancer HRD+ ARIEL3

    3

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F2b
      3
    Rucaparib - Placebo Maintenance treatment of patients with platinum sensitive relapsed high-grade epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in response (complete or partial) to platinum-based chemotherapy ARIEL3
    Gynaecological Malignancies
    		 Ovarian, fallopian tubes and peritoneum cancer BRCA-mut ARIEL3

    3

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F2b
      3
    Rucaparib - Placebo Maintenance treatment of patients with platinum sensitive relapsed high-grade epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in response (complete or partial) to platinum-based chemotherapy ARIEL3
    Gynaecological Malignancies
    		 Ovarian, fallopian tubes and peritoneum cancer - ARIEL3

    3

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F2b
      3
    Atezolizumab Carboplatin and etoposide Placebo plus carboplatin and etoposide First-line treatment of extensive-stage SCLC IMpower133
    Thoracic Malignancies
    		 Small-cell lung cancer - IMpower133

    3

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      3
    Pembrolizumab - Cisplatin or carboplatin/5-FU/cetuximab As monotherapy is indicated for the first‑line treatment of metastatic or unresectable recurrent head and neck squamous cell carcinoma in adults whose tumours express PD‑L1 with a CPS ≥ 1 KEYNOTE-048
    Head and neck cancer
    		 Squamous cell CPS PD-L1 expression ≥1 KEYNOTE-048

    4

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      4

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