ESMO-MCBS Scorecards

Evaluation form 1  For new approaches to adjuvant therapy or new potentially curative therapies

Evaluation form 2a For therapies that are not likely to be curative with primary endpoint of OS with separate sheets for:

• IF median OS with the standard treatment is ≤ 12 months
• IF median OS with the standard treatment is >12 months, ≤24 months
• IF median OS with the standard treatment is >24 months

Evaluation form 2b For therapies that are not likely to be curative with primary endpoint PFS with separate sheets for:

• IF median PFS with standard treatment is ≤ 6 months
• IF median PFS with standard treatment is >6 months

Evaluation form 2c  For therapies that are not likely to be curative with primary endpoint other than OS or PFS or equivalent (non-inferiority) studies

Evaluation form 3  For single-arm studies in orphan diseases and for diseases with high unmet need when primary outcome is PFS or ORR.

To evaluate ESMO-MCBS score adjustments based on quality of life .