Efficacy and Safety of Entrectinib in Advanced ROS1 Fusion–Positive Non–Small Cell Lung Cancer
Results of an updated integrated analysis of the ALKA-372-001, STARTRK-1, and STARTRK-2
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1549 results
FDA Approves Tivozanib for Relapsed or Refractory Advanced Renal Cell Carcinoma
Evidence for efficacy is based on the results from the TIVO-3 study
Whole-Genome Sequencing Provides Rapid and Accurate Genomic Profiling in Patients with AML or MDS
Clinical utility of whole-genome sequencing demonstrated for the genomic evaluation of patients with acute myeloid leukaemia or myelodysplastic syndromes
FDA Approves Lorlatinib for Metastatic ALK-positive Non-Small Cell Lung Cancer
FDA also approved the Ventana ALK (D5F3) CDx Assay as a companion diagnostic for lorlatinib
NEOSTAR Results Indicate that Neoadjuvant Nivolumab Plus Ipilimumab Enhances Pathologic Responses in Operable NSCLC
Phase II randomised study met prespecified primary endpoint threshold in patients with operable non-small cell lung cancer
EMA Recommends Granting a Marketing Authorisation for Generic Abiraterone for the Treatment of Metastatic Prostate Cancer
Abiraterone Accord is a generic of Zytiga, which has been authorised in the EU since 2011
Significant Benefits of Nivolumab Plus Cabozantinib Over Sunitinib in Previously Untreated Advanced RCC
Results of CheckMate 9ER study in patients with previously untreated advanced clear cell renal-cell carcinoma
EMA Recommends Extension of Therapeutic Indications for Cabozantinib and Nivolumab
Combination of cabozantinib and nivolumab is indicated for the first-line treatment of adult patients with advanced renal cell carcinoma
Results of Pivotal Study with BCMA Specific CAR T-Cell Therapy in Patients With Refractory and Relapsed Multiple Myeloma
Substantial antitumour activity observed with idecabtagene vicleucel in the KarMMa study
Poziotinib Shows Promise in EGFR and HER2 Exon 20 Mutated Non-Small Cell Lung Cancer
Twice daily poziotinib dosing improved the adverse event profile; early results showed retained anti-tumour activity
Pan-FGFR Tyrosine Kinase Inhibitor Treatment Is Less Effective in Patients with FGFR Amplifications
Clinical benefit of FGFR inhibition is stronger in patients with an FGFR fusion or mutation compared to FGFR amplification
Tumour Signatures Defined by Next Generation Sequencing Are Linked to Clinical Response in Breast Cancer
Endogenous and exogenous mutational processes driven by abnormal DNA editing, mutagens or age-related DNA alterations over the history of a malignant tumour provide an individual tumour signature