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Endogenous and exogenous mutational processes driven by abnormal DNA editing, mutagens or age-related DNA alterations over the history of a malignant tumour provide an individual tumour signature
Prelliminary data with IL-12 mRNA administered by intratumoural injection in combination with intravenous durvalumab
Overall, more adverse events were reported with targeted therapies than with immunotherapy.
Many cancer patients with autoimmune disease are excluded from studies of immune checkpoint inhibitors due to hypothesis of the association of this treatment with immune-related adverse events
It is intended for the treatment of recurrent or advanced dMMR/MSI-H endometrial cancer that has progressed on or following prior treatment with a platinum-containing regimen
A need for immediate restoration of breast cancer screening at full capacity
After 9.1 years of follow-up, a trend toward better long-term imatinib failure-free survival in imatinib treated patients was observed in high-risk subgroup
Approval concerns the treatment of patients with tumours without EGFR, ALK or ROS1 aberrations
Tisagenlecleucel outcomes in relapsed or refractory DLBCL and follicular lymphoma
Long-term follow-up due to risk of cancer
Real-world findings
Cardiac safety is confirmed with longer follow-up after adjuvant dual anti-HER2 treatment for node-positive, HER2-positive early breast cancer
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