FDA Approves Selpercatinib for Locally Advanced or Metastatic RET Fusion-Positive NSCLC
FDA also approved the Oncomine Dx Target Test as a companion diagnostic for selpercatinib
Oncology News
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Utility of Genomic Profiling of cfDNA to Inform Clinical Care for Patients with Advanced Biliary Tract Cancer
Limitations of cfDNA for detection of FGFR2 fusions
Higher Efficacy, But Also More Toxicity of Axicabtagene Ciloleucel Compared to Tisagenlecleucel in Relapsed/Refractory DLBCL
Findings from an individual patient data based matched comparison of efficacy and safety between two commercial CAR T cell products
Clinical Utility of ctDNA NGS for Detecting Actionable Alterations According ESCAT in Patients with Advanced Cancer
Findings from the French National Center for Precision Medicine
EMA Recommends Extension of Indications for Crizotinib
Two new indications concern the treatment of paediatric patients with ALK-positive anaplastic large cell lymphoma and inflammatory myofibroblastic tumour
EMA Recommends Granting a Conditional Marketing Authorisation for Loncastuximab Tesirine
It is indicated for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma and high-grade B-cell lymphoma
EMA Recommends Extension of Indications for Axicabtagene Ciloleucel
New indication concerns the treatment of patients with diffuse large cell lymphoma and high-grade B-cell lymphoma
RNF43 Mutations Warrant Further Validation for Potential to Prioritise Anti-EGFR/BRAF Combinations in Selected Patients with BRAFV600E-Mutated mCRC
Findings from an assessment of predictive value of RNF43 status in patients with BRAFV600E-mutated metastatic colorectal cancer
EMA Recommends Extension of Indications for Zanubrutinib
New indication concerns treatment of adult patients with marginal zone lymphoma who have received at least one prior anti-CD20-based therapy
Phase II LCMC3 Study of Neoadjuvant Atezolizumab Met Primary Endpoint with a Major Pathological Response Rate of 20% in Resectable Stage IB–IIIB NSCLC
Results of the largest study of preoperative immune checkpoint inhibitor monotherapy in patients with early-stage non-small cell lung cancer to date
FDA Approves Ibrutinib for Paediatric Patients with Chronic Graft Versus Host Disease, Including a New Oral Suspension
Evidence for efficacy is based on the results from the iMAGINE study
FDA Approves Durvalumab for Locally Advanced or Metastatic Biliary Tract Cancer
Evidence for efficacy is based on the results from the TOPAZ-1 study