EMA Recommends Granting a Conditional Marketing Authorisation for Autologous Anti-CD19-Transduced CD3+ Cells
Intended use is for the treatment of relapsed or refractory mantle cell lymphoma
Oncology News
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FDA Extends Approval of Pembrolizumab for Classical Hodgkin Lymphoma
Approval was based on KEYNOTE-204
EMA Recommends Extension of Indications for Nivolumab
New indication concerns the treatment of patients with unresectable advanced, recurrent or metastatic oesophageal squamous cell carcinoma
Targeted Therapy Based on Molecular Profiling of Malignant Mesothelioma Tumours Is Feasible
First evidence that patients with malignant mesothelioma have gender specific differences in PDGFRα expression
Larger NGS Gene Panel Linked to More Clinical Utility
Evaluation of the clinical utility of two different size next-generation sequencing gene panels in solid tumours showed a preference for a larger panel across all tumour types investigated
Triple Blockade Demonstrates High Response Rates in Metastatic Melanoma
Response was found to associate with specific biomarkers and biomarker modulations following treatment
The Nobel Prize in Chemistry 2020 was Awarded “for the Development of a Method for Genome Editing”
CRISPR/Cas9 system has had a revolutionary impact on the life sciences, contributing to development of new cancer therapies
Fragment Analysis Is a More Reliable MET Exon 14 Screening Strategy for Identifying Large Deletions
MET alterations may identify candidates for targeted therapy and signal decreased immunotherapy benefit in NSCLC
Patients with Early Stage NSCLC Have a Higher TMB in Comparison to Advanced Stage Disease
Tumour mutational burden and molecular signatures may indicate potential benefit from immunotherapy in early stage non-small cell lung cancer
Radiation-Induced ‘Genomic Scars’ Associate with Poor Patient Outcome
Findings from an analysis of mutational spectra following radiotherapy
EMA Reminds Physicians to Use Atezolizumab with Nab-paclitaxel for Treating TNBC
Advice follows the release of results from the IMpassion131 study
FDA Approves Nivolumab and Ipilimumab for Unresectable Malignant Pleural Mesothelioma
Evidence for efficacy is based on the results from the CheckMate-743 study