Germline Pathogenic Variants in CDH1, BRCA2, CHEK2, ATM, and PALB2 Associated with Increased Risk of Invasive Lobular Carcinoma
Multigene panel testing may be appropriate for women with invasive lobular carcinoma and to identify women at risk
Oncology News
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Cure Probability Models for Evaluation of Patients with a Previous Cancer Diagnosis for Solid Organ Transplantation
Evaluation and referral of patients with cancer based on cure probability could increase safety and overall population-level benefit of transplantation
EMA Recommends Granting a Marketing Authorisation for Sacituzumab Govitecan
It is indicated for the treatment of adult patients with unresectable or metastatic TNBC who have received two or more prior systemic therapies
FDA Approves Atezolizumab as Adjuvant Treatment for Non-Small Cell Lung Cancer
Evidence for efficacy is based on the results from the IMpower010 study
EMA Recommends Granting a Marketing Authorisation for Zanubrutinib for the Treatment of Waldenström’s Macroglobulinaemia
It is indicated in patients who have received at least one prior therapy, or in first-line treatment for patients unsuitable for chemo-immunotherapy
Nivolumab Plus Low-Dose Ipilimumab Demonstrates Clinical Benefit in First-Line Treatment for MSI-H/dMMR mCRC
Findings from the CheckMate 142 study in patients with microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer
Adjuvant Abemaciclib Combined with Endocrine Therapy Improves IDFS in HR-Positive, HER2−Negative, Node-Positive, High-Risk, Early Breast Cancer
Updated results from the monarchE study point to abemaciclib benefit regardless of Ki-67 status
Zilovertamab Vedotin Is Safe and Demonstrates Activity In Heavily Pretreated Patients With Lymphoid Malignancies
Findings from a phase I study of selective ROR1 targeting
FDA Approves Pembrolizumab Combination for the First-Line Treatment of Cervical Cancer
Evidence for efficacy is based on the results from the KEYNOTE-826 study
EMA Recommends Extension of Indications for Pembrolizumab
New indication concerns the treatment of PD-L1 positive locally recurrent unresectable or metastatic TNBC
TMB Consortium Develops a TMB Calibration Tool
Statistical calibration allows for comparison of tumour mutational burden values across various panel assays
A Third Dose of BNT162b2 is Safe and Improves Humoural Immunity Against SARS-CoV-2 in Patients with Solid Tumours
Third vaccine dose could be immunologically beneficial for patients on active chemotherapy