Increased Efficacy of Pembrolizumab or Pembrolizumab-Chemotherapy with Increasing PD-L1 Expression in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Subgroup analysis by PD-L1 combined positive score in KEYNOTE-048 study
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Subgroup analysis by PD-L1 combined positive score in KEYNOTE-048 study
Findings from the single-arm phase II study
New indications concern the treatment of patients with MSI-H or dMMR advanced colorectal, endometrial, gastric, small intestine, or biliary cancers, and PD-L1-positive metastatic cervical cancer
Long-term outcomes and exploratory analyses from the BILCAP study
It also approved the VENTANA MMR RxDx Panel as a companion diagnostic device to select patients with dMMR in solid tumours
The risk to develop peritoneal carcinomatosis increases over time
Detection of ctDNA using sensitive personalised assays can inform patient prognosis and help guide patient treatment
It is intended for the treatment of adult patients with unresectable or metastatic HLA A*02:01 positive uveal melanoma
Findings from a post-hoc analysis of IDEA-France
Patients with cancer, especially haematologic malignancies, are at higher risk for developing breakthrough infections and severe outcomes
New mechanisms of genomic escape from established covalent and novel non-covalent Bruton’s tyrosine kinase inhibitors described
Safety and efficacy were evaluated in CARTITUDE-1 study
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