Modest Effectiveness of Screening Colonoscopy for the Prevention of Colorectal Cancer in a Large, Population-Based, Randomised Study
Findings from the NordICC Study Group trial
Oncology News
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EMA Recommends Granting a Marketing Authorisation for Generic Sorafenib
Sorafenib Accord is a generic of Nexavar, which has been authorised in the EU since 2006
FDA Grants Accelerated Approval to Futibatinib for Cholangiocarcinoma
Efficacy was evaluated in TAS-120-101 study in patients with previously treated, unresectable, locally advanced, or metastatic intrahepatic cholangiocarcinoma harbouring a FGFR2 gene fusion or other rearrangement
GPRC5D Is An Active Immunotherapeutic Target in Multiple Myeloma
Findings from a phase I, dose-escalation study of a second-generation CAR T-cells in patients with relapsed or refractory multiple myeloma
Adjuvant Nivolumab Plus Ipilimumab Combination Does Not Improve RFS Over Nivolumab Alone in Patients with Stage IIIB-D or IV Melanoma
Findings from the CheckMate 915 study primary endpoints of recurrence-free survival in the all randomised population and in patients with tumour PD-L1 expression < 1%
Fourth Vaccine Dose Increases in Humoral Immunity Against Omicron Variants in Patients with Cancer
Passive immunisation with tixagevimab and cilgavimab may not be effective
FDA Approves Selpercatinib for Locally Advanced or Metastatic RET Fusion-Positive Solid Tumours
Evidence for efficacy is based on the results from the LIBRETTO-001 study
FDA Approves Selpercatinib for Locally Advanced or Metastatic RET Fusion-Positive NSCLC
FDA also approved the Oncomine Dx Target Test as a companion diagnostic for selpercatinib
Utility of Genomic Profiling of cfDNA to Inform Clinical Care for Patients with Advanced Biliary Tract Cancer
Limitations of cfDNA for detection of FGFR2 fusions
Higher Efficacy, But Also More Toxicity of Axicabtagene Ciloleucel Compared to Tisagenlecleucel in Relapsed/Refractory DLBCL
Findings from an individual patient data based matched comparison of efficacy and safety between two commercial CAR T cell products
Clinical Utility of ctDNA NGS for Detecting Actionable Alterations According ESCAT in Patients with Advanced Cancer
Findings from the French National Center for Precision Medicine
EMA Recommends Extension of Indications for Crizotinib
Two new indications concern the treatment of paediatric patients with ALK-positive anaplastic large cell lymphoma and inflammatory myofibroblastic tumour