Multi-omics Study of Gut Microbiota in Colorectal Cancer
Shifts in microbiome and metabolome occur early in colorectal cancer development
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Shifts in microbiome and metabolome occur early in colorectal cancer development
Combinations of immune checkpoint inhibitor and targeted therapies show tolerability and promising efficacy
Approval is based on evidence from AUGMENT and MAGNIFY trials
PARP inhibitors benefit observed beyond treatment for breast and ovarian cancers
Approval is based on evidence from the ADMIRAL trial
Targeting alternative immune pathways
It is intended for protecting the kidneys against radiation during PRRT with lutetium (177Lu) oxodotreotide.
It also approved the companion diagnostic test to select patients who have PIK3CA mutations in tumour tissue specimens and/or in ctDNA
Understanding underlining mechanisms is crucial to boost a weak antitumour immunity
It is approved for steroid-refractory GVHD in adult and paediatric patients 12 years and older
Patients with actionable tumour alterations should receive targeted therapies and chemotherapy before considering immunotherapy
Available instruments may not be capable of ascertaining all relevant domains
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