5
Indication details
- Control Arm
- Gemcitabine
- Therapeutic Indication
- First-line metastatic pancreatic cancer in patients with good performance status
- Tumour Type
-
Gastrointestinal Cancers
- Tumour Sub-type
- Pancreatic cancer
- Tumour Stage
- Metastatic
- Trial Name
- PRODIGE 4/ACCORD 11
- NCT Number
- NCT00112658
- Trial Phase
- Phase II/III
Primary Outcome(s)
- Primary Outcome(s)
- OS (crossover allowed)
- Evaluated Outcome
- OS
- Form(s)
- Form 2a
Outcome Data
- OS Control
- 6.8 months
- OS Gain
- 4.3 months
- OS HR
- 0.57 (0.45-0.73)
Adjustments
- QoL Comment
-
Delayed deterioration in QoL
Score (after adjustments)
- Preliminary non-curative score
-
4
- QoL adjustment
- 1+
- Non-curative score
-
5
- Comment
-
Regimen without a specific licensed indication in pancreatic cancer.
Scorecard details
- ESMO-MCBS version
- ESMO-MCBS v1.1
- Scorecard ID
- 33
- Scorecard version
- 1
- Issue date
- 11.12.2018
Legend
Information about symbols, abbrevations and color codes
Red = negative
Green = positive
Grey = neutral
?
Grey + ? = neutral with pending data
- DFS
- Disease-Free Survival
- DoR
- Duration of Response
- EFS
- Event-Free Survival
- HR
- Hazard Ratio
- NEB
- No evaluable benefit
- NI
- Non-inferiority Study
- ORR
- Overall Response Rate
- OS
- Overall Surival
- pCR
- Pathological Complete Response/Remission
- PFS
- Progression-Free Survival
- QoL
- Quality of Life
- RFS
- Relapse-Free Survival
- RR
- Response Rate
QoL adjustments
Other adjustments*
Serious and disabling adverse effects
Red = negative / deterioration
Green = positive / improvement
QoL adjustments
Red = negative / deterioration
Green = positive / improvement
Other adjustments*
Red = negative / deterioration
Green = positive / improvement
Serious and disabling adverse effects
Red = negative / deterioration
Green = positive / improvement
* Other adjustments include:
- Long-term plateau in the survival curve
- Long-term plateau in the PFS curve
- Early stopping or crossover
- Only improved PFS mature data shows no OS advantage and no improved Qol.