My main research interests are gastrointestinal oncology, early phase clinical trials and translational research. I pioneered Hong Kong Liver Cancer classification, which has revolutionized the treatment algorithm of liver cancer patients.  Moreover, I am actively involved in cancer drug development, especially in the field of cancer immunotherapy.  I have led a few global ground-breaking immunotherapy trials for liver cancer and some of these trials led to global drug approval for advanced hepatocellular carcinoma patients.  I have published more than 140 peer-review publications with first author articles in various leading oncology journals, namely Lancet, JAMA Oncology, Gastroenterology, and Journal of Hepatology. My latest H index is 49 with over 10000 citations in the literature.  I am the recipient of projects funded by, Theme-based Research Scheme and General Research Fund, University Grant Committee in Hong Kong.  I also received Innovation and Technology Fund and Hong Kong Health and Research Fund as well.

Internationally, I am currently the faculty member of the European Society of Medical Oncology (ESMO) in gastrointestinal cancer and a member of The Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of hepatocellular carcinoma.  I am also vice president of Asia Pacific Neuroendocrine Tumour Society, council member of The Asia-Pacific Primary Liver Cancer Expert (APPLE) Association and International Faculty Board Member of International Association of Surgeons Gastroenterologist and Oncologists and member of many international professional societies.  Previously, I was an international member of US NCI Hepatobiliary Task Force. In Hong Kong, I am a general secretary of Hong Kong Liver Cancer Foundation and council member of Hong Kong Sustainable Council.

I have delivered more than 200 regional and international invited and plenary lectures.  I have received Supervisor award and Young Investigator award from the Hong Kong College of Physician in 2011 and 2014, respectively.  Notably, he was the orator of Richard Yu lecture in the Hong Kong College of Physicians for his seminal work in liver cancer in 2019.  He currently serves as associate editor and the editorial board members of many international peer-reviewed journals.