Rille is currently a consultant medical oncologist at St Bart's Hospital in London. She is originally from Estonia and finished her undergraduate medical degree and postgraduate training in Oncology there in 2016. She was then awarded The Collins/Pancreatic Cancer UK Clinical Research PhD Fellowship at The University of Manchester/The Christie NHS Foundation Trust. She successfully defended her PhD on pancreatic cancer in 2021 and then joined The Royal Marsden GI unit for a Senior Research Fellowship. In 2022 she was appointed as a consultant medical oncologist in GI cancers at St Bart's Hospital.

Outside of her current clinical role, she has various other international roles like being a member of the ESMO Young Oncologist Committee and co-chair of the Postgraduate Medical Education Committee in The International Association for Medical Education (AMEE).