George Pentheroudakis (born 3/12/1967) holds an MD degree from the Aristotle University of Thessaloniki, Greece (1991). He specialized in Internal Medicine in Thessaloniki, Greece (1993-1999). Subsequently he trained in Medical Oncology at the Beatson Oncology Centre, Glasgow, United Kingdom (1999-2002).

Returning to Greece in 2003, he defended his PhD thesis and worked as a Consultant Medical Oncologist at the Department of Medical Oncology, University of Ioannina, Greece. He joined the Medical School faculty, University of Ioannina, Greece as Assistant Professor in 2010 and became Head of Department of Oncology in 2016 and Professor of Oncology in 2018, where he established a Translational and Clinical Research Unit, a Palliative and Supportive Care Unit and a Liquid Biopsy Unit. He had regular teaching duties and was actively involved in translational research in cancer and in early phase I-II studies evaluating novel agents in collaboration with national and international groups.

He served as Chair of the Scientific Committee of the Hellenic Cooperative Oncology Group (HeCOG) from 2012 to 2016. His main research interests are gastrointestinal cancer, cancer of unknown primary, translational cancer research.

Since August 2020, Professor Pentheroudakis serves as ESMO Chief Medical Officer, after having served as Guidelines Committee Chair (2016-2020), member of the Executive Board (2016-2018) and as ESMO CUP and Endocrine Tumour Faculty Coordinator. He has (co)-authored 342 PubMed-indexed peer-reviewed papers and speaks Greek, English, French and Italian.